Therapeutically, CoNS are challenging due to the large proportion of methicillin-resistant strains and increasing numbers of isolates with less susceptibility to glycopeptides. In this regard, host susceptibility is much more important. aureus, with a respectively different disease spectrum. Clearly, CoNS possess fewer virulence properties than S.
This blurred gradation in terms of pathogenicity is reflected by species- and strain-specific virulence factors and the development of different host-defending strategies. In addition to CoNS found as food-associated saprophytes, many other CoNS species colonize the skin and mucous membranes of humans and animals and are less frequently involved in clinically manifested infections. aureus in causing infectious endocarditis. lugdunensis has a unique status, in some aspects resembling S. saprophyticus has been associated with acute urethritis, S. They account substantially for foreign body-related infections and infections in preterm newborns. haemolyticus being the most significant species. Due to patient- and procedure-related changes, CoNS now represent one of the major nosocomial pathogens, with S. The definition of the heterogeneous group of coagulase-negative staphylococci (CoNS) is still based on diagnostic procedures that fulfill the clinical need to differentiate between Staphylococcus aureus and those staphylococci classified historically as being less or nonpathogenic.
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